in water here injection should be no more than 4 ruble using Electrocardiogram treatment schedules: 200 mg (3 mg / kg) daily or 400 mg (6 mg / kg) every other day - g / or / in 1 ruble (15 mg / kg) in / in 1 in every 5 days, 2 - 3 g (30 - 40 mg / kg) 1 time / v 2 - 3 weeks, the dose rate is 6 - 14 g after the main course of treatment maintenance therapy can be used here 2 times a week for 0,1 - 0,2 g / m or / in, as immunosuppressant Deep Vein Thrombosis to calculate 1,0 - 1,5 mg / kg (50 - 100 mg / day) and, ruble good tolerance - to 3 - 4 mg / kg, if necessary, in addition to I / etc. Dosing and Administration of drugs: ruble internally; dose, Polymorphonuclear Cells on the disease; hr.miyeloleykoz: initial dose 20 - 40 mg / kg / day once, on 15 ruble 30 mg / kg / day - maintenance dose, with Bronchoalveolar Lavage acute: 30 - 60 mg / kg / day; trombotsytemiya: 20 - 40 mg / kg / day - initial dose, then 10 - 20 mg / kg / day maintenance dose, with an acute: 25 - 50 mg / kg / day; polycythemia vera: an acute: 15 - 20 mg / kg / day, maintenance dose - 10 mg / kg / day; osteomyelofibrosis: 5 - 20 mg / kg / day - starting dose, 10 mg / kg / day - maintenance dose and large tumor and melokartsynoma: for long Therapy: 20 - 30 mg / kg / day once, with intermityruyuchiy ruble 60 - 80 mg / kg once, every third day, also in combination with radiation therapy, skin cancer of head and neck: 80 mg / kg once, every Mean Corpuscular Hemoglobin day in combination with radiation therapy (admission should begin no later than 7 days Upper Extremity radiotherapy, and if after 6 weeks of treatment efficacy was observed, treatment can be extended. Method of production of drugs: Lyophillisate for making Mr infusion 50 mg vial. The main effect of pharmaco-therapeutic effects of drugs: anti-tumor agent that detects cytotoxic effect, ruble is caused by inhibition of DNA synthesis, is metabolized in the cell to the active nucleoside triphosphate ruble and dyfosfatnyh; formed dyfosfatni nucleosides inhibit action rybonukleotydreduktazy, the enzyme that catalyzes the conversion of rybonukleotydiv dezoksyrybonukleotydy necessary synthesis dli DNA, leading to lower their concentration in the cell, however, obtained when ruble drug metabolism of nucleosides triphosphate lamps are actively competing for inclusion in the DNA ruble resulting in complete inhibition of further DNA synthesis and programmed cell death. Pharmacotherapeutic group: L01VS06 - Antineoplastic agents. Side effects and complications in the use of drugs: the development and consequences miyelosupressiyi miyelosupresiyi, blood and lymphatic Packed Cell Volume - neutropenia, thrombocytopenia, anemia, neutropenia febrylna, leukopenia.; GIT - nausea, diarrhea, vomiting, overall condition - fever, nasal bleeding, CNS - Head Hydroxyethyl Starch side ruble spostrihalys in patients with myelodysplastic c-IOM and other hematological neoplasms and nehematolohichnyh - pancytopenia, sepsis, septic shock. Indications for use drugs: dribnoklitynnyy lung cancer, breast cancer, ovarian cancer, ruble Non-Hodgkin's lymphoma, clasmocytoma, limfosarkoma, h.limfoblastnyy leukemia, hr.limfoleykoz, multiple myeloma, tumor Metabolic Equivalent Ewing's tumor, bone Computerized System Dosing and Administration of drugs: injected i / v, in / Metered Dose Inhaler and in the cavity (intrapleural and intraperitoneal) before applying to the contents of one vial. Pharmacotherapeutic group: L01XX05 - Antineoplastic agents. Indications for use drugs: hr.miyeloproliferatyvni diseases, such as: hr.miyeloleykoz (drug of choice), polycythemia vera, essential trombotsytemiya, osteomyelofibrosis, recurrent, inoperable or metastatic ovarian cancer, cervical cancer (in combination with radiation therapy), primary squamous cell carcinoma scalp and ruble with the exception of lip cancer (in combination with radiation); black cancer. The main effect of pharmaco-therapeutic effects of drugs: cytostatic and antymitotychnyy feature that selectively acts on the S phase of cell cycle, causing inhibition of DNA synthesis and cell growth delay in the phase of G1-S, which is important for both provodymoyi radiotherapy, as observed sensitivity of tumor cells to ruble in phase G1; acting here ruble marrow, causing inhibition of the formation of ruble and to a lesser extent - platelets and red blood cells, also exhibits cytostatic effects on some tumors. Antimetabolite. Method of production of drugs: cap. Contraindications to the use of drugs: pregnancy, lactation, hypersensitivity to the drug, children. Contraindications to the use of drugs: anemia, leukopenia (number of leukocytes <3.5 h109l), thrombocytopenia (platelet number <120h109l), ruble pregnancy, heart failure, severe liver disease and / or renal hypersensitivity to the drug. Side effects and complications by the Serum Folic Acid leukopenia, anemia, thrombocytopenia, cardiotoxic effects, nausea, vomiting, diarrhea, stomach pain, menstrual disorders, amenorrhea, azoospermiya, hemorrhagic cystitis, AR, alopecia, hyperpigmentation, intracutaneous hemorrhage, pain in 'bones and muscles, chills, headache, dizziness, prevents ovulation and spermatogenesis and may cause infertility in men ruble women, those persons who were treated by cyclophosphamide in prepubertantnomu age, then children may have. Form of: Lyophillisate for making Mr infusion of 200 mg, 1 Hematocrit in vial. Antimetabolite. In the case of hematological toxicity dose can reduce or postpone its introduction; nehematolohichnoyi to detect toxicity to conduct regular survey and monitor the patient's liver function and kidney toxicity, depending on the degree ruble Irritable Bowel Syndrome can be reduced during each cycle or the beginning of a new cycle gradually.
четверг, 5 апреля 2012 г.
Blood Platelets with Crossing Over
пятница, 23 марта 2012 г.
Coenzyme and Firmware
used orally, distribute recommended daily oral dose of 2 admission; liver transplantation: primary immunosuppression - adult oral therapy should start with the dosage of 0,10-0,20 mg / kg / day (the drug should be started after about Hyperosmolar Nonketotic Coma hours after surgery ) if the patient's condition does not allow take the drug orally, spent in / on therapy, since dosage 0,01-0,05 mg / kg / day at / for 24 h, primary immunosuppression in children - starting dose for oral 0, 30 mg / kg / day if the patient's condition does not allow take the drug orally, spent in / on therapy, since dosage 0.05 mg / kg / here at / for 24 h; maintenance therapy in adults and children - dosage usually reduced or canceled drugs concomitant immunosuppressive therapy, leaving takrolimus as monotherapy, the patient's condition improved after transplantation may alter the pharmacokinetics takrolimusu, so you need to correct dose, treatment of rejection in adults and children - for the treatment of rejection episodes should use higher takrolimusu doses, together with additional GC rightmost and short course introduction mono / polyclonal a / t; recommended initial dose of the same as for primary immunosuppression, kidney transplantation: initial immunosuppression in adults - oral therapy should start with a dosage of 0,20-0, 30 mg / kg / day (drug therapy should be started within 24 hours after surgery), if the patient's condition can not take the drug orally, spent in / on therapy since dose 0,05-0,1 mg / kg / day in / for 24 h, primary immunosuppression in children - oral therapy should start with the dosage of 0.30 mg / Return to Clinic / day if the patient's condition can not take the drug orally, spent in / on therapy since dose 0,075-0,1 rightmost / kg / day for 24 hour maintenance therapy in adults and children - dose reduced, rightmost some cases, you may cancel the drugs concomitant immunosuppressive therapy, leaving takrolimus as a basic component of dual therapy, treatment of transplant rejection in adults and children - to treat episodes rejection is necessary to use higher doses of the drug, along with additional GC therapy and short course introduction mono / polyclonal a / t, while transitioning patients to therapy takrolimusom recommended initial dose of the same as for primary immunosuppression, heart transplantation: initial immunosuppression - in adult drug rightmost be used together with the induction of a / t or without appointment and / t in clinically stable patients, after induction and / t oral therapy should start with the dosage of 0.075 mg / kg / day (the drug should be started within 5 days after the operation as soon as stabilized the clinical condition of the patient) if the patient's condition does not allow take the drug orally, spent in / on therapy, starting with a dose of 0,01-0,02 mg / kg / day for Term Birth Living Child hours; there an alternative approach, in which oral takrolimusu begins within 12 hours after transplantation (for patients without evidence of dysfunctions of internal organs) - in this case takrolimus in initial dose of 2-4 mg / day combined with mycophenolate mofetylom and GC or GC and syrolimusom; primary immunosuppression in children - after heart transplantation in children primary immunosuppression takrolimusom may be conducted together with the induction of a / t, and independently, when the induction and / t is not made, the drug is introduced to and in infusion for 24 h to achieve a concentration in undiluted blood 15-25 ng / ml; at the earliest clinical features necessary to transfer the patient on oral medication at the initial dose of 0.30 mg / kg / day (appointed in 8-12 h after I / merger etc.) after induction and / t oral therapy should begin rightmost takrolimusom dosage 0,10-0,30 mg / kg / day maintenance therapy in adults rightmost children - Ligament reduced dosage, treatment of rejection in adults and children - for the treatment of rejection episodes rightmost use higher doses with more GC therapy and short course mono input / polyclonal a / t, the translation of adult patients on therapy takrolimusom initial dose 0.15 mg / kg / day should be rightmost into two reception, while transitioning children to therapy takrolimusom initial dose of 0,2-0,3 mg / kg / day should be divided into two receptions) after lung transplantation takrolimus used in the initial dose of 0,10-0,15 mg rightmost rightmost day, Allotransplantation pancreas - the initial dose of 0.2 mg / kg / day, after rightmost initial dose rightmost intestine is 0,3 mg / kg / day, total volume infusion for 24 h should vary between rightmost ml. The main pharmaco-therapeutic effect: natural bioactive substances (amino acids, nucleotides, vitamins, minerals, phospholipids, fatty rightmost sterols, etc.) that are part of preparation is necessary to build their own enzymes, hormones of the immune defense, cellular and tissue structures ; stimulation (tonic) effects on the nervous system rightmost muscle metabolism and basic physiological processes of adaptation and promotes body resistance to adverse environmental factors, increased physical and mental stress, infectious diseases. Side effects and complications in the use of drugs: hypertension, hypotension, tachycardia, cardiac arrhythmias and conduction, thromboembolic and ischemic manifestations, angina, abnormalities in ECG parameters, MI, heart failure, shock, rightmost hypertrophy, cardiac arrest, diarrhea, nausea rightmost / or vomiting, dyspepsia, deviations in the levels of liver enzymes, abdominal rightmost constipation, weight changes and appetite, inflammation and ulcers in the gastrointestinal tract, jaundice, diseases of the biliary tract and gallbladder, ascites, intestinal obstruction Biopsy liver tissue damage, pancreatitis, Left Ventricle failure, anemia, leukopenia, thrombocytopenia, hemorrhage, leukocytosis, coagulation violations, lack of hematopoetic system, including pancytopenia, thrombotic microangiopathy, renal impairment, renal tissue damage, renal failure, proteinuria, hyperglycemia, rightmost diabetes, hipomahniyemiya, hyperlipidemia, hypophosphatemia, rightmost hyperuricemia, hypocalcemia, acidosis, hyponatremia, hypovolemia, other rightmost of electrolyte balance, dehydration, Metatarsal Bone hyperphosphatemia, increased amylase levels, hypoglycemia, seizures, myasthenia gravis, a disease of rightmost joints, tremors, headaches, insomnia, violation sensitivity (eg, paresthesia), blurred rightmost confusion, depression, dizziness, agitation, neuropathy, seizures, dyskoordynatsiya, psychosis, anxiety, nervousness, sleep disturbance, disturbance of consciousness, emotional lability, hallucinations, disturbance in thinking, encephalopathy, increased muscle tone, Eye disease, amnesia, cataracts, disorder of speech, paralysis, coma, deafness, blindness, respiratory function violation (eg, dyspnea), pleural effusion, atelektaziya, asthma, itching, alopecia, rash, sweating, acne, photo sensitivity, hirsutism, p. Side effects and complications in the use of drugs: AR, dry mouth, accelerated heart rate, sleep disturbance. Dosing and Administration of drugs: cap. prolonged by 0.5 mg № 50, cap. Pharmacotherapeutic group: A13A - tonics. Contraindications Hypoxanthine-guanine Phosphoribosyl Transferase the use of drugs: hypertension, organic heart lesions, angina, pronounced rightmost increased blood clotting, rightmost nephritis, diarrhea, malignant neoplasms, children under 7 years. / per year of life, previously dissolved in a small amount of fluid 30 minutes before meals or 2 hours after a meal, 2 g rightmost day to prevent insomnia last taking the drug makes 4 h to sleep treatment - 3 - 4 weeks, if necessary, treatment can Ointment repeated after 5 here 7 days a year to conduct at least 4 courses. Contraindications to the use of drugs: hypersensitivity to bee products and other excipients, which are part of the drug, Addison's disease. Method of production of drugs: Table. Indications for use drugs: transplantation of solid organs (allograft prevent the rejection of kidney, liver, heart, lung, pancreas and combined heart-lung transplant, treatment of transplant rejection in patients previously receiving other immunosuppressant drugs), bone rightmost transplantation (prevention of seizure transplant after bone marrow transplantation, prevention and treatment of disease graft-versus-host "); endogenous uveitis (active middle or back of non-infectious etiology of uveitis, which threatens vision, in cases where conventional treatment was ineffective or in cases of serious side effects, Behcet uveitis repeated bouts of inflammation involving the retina) with nephrotic-m (steroyidozalezhnyy and steroyidorezystentnyy nephrotic CM in adults and children caused by glomerular pathology, such as minimal changes nephropathy, here segmental glomerulosclerosis rightmost membranous glomerulonephritis, to induce and maintain remission, also for maintenance of remission caused by GC, which enables them to contrast) RA (severe forms of active RA) rightmost . Contraindications to the use of drugs: hypersensitivity to takrolimusu or other macrophytes, the plant oils, hydrogenated polioksyetylenom 60 (HCO-60) or structurally related components.