Contraindications to the use of drugs: hypersensitivity to the drug, active liver disease or persistent increase activity of the serum transaminases, pregnancy and lactation, children under 9. Side effects and complications in the use of drugs: thrombocytopenia, insomnia, headache, paresthesia, dysesteziyi, hipoesteziyi to which is also known connection with hyperlipidemic disorders, vasculitis, dyspepsia, abdominal pain, nausea, pancreatitis, hepatitis, rash, urticaria, other skin reactions, swelling of face, angioedema, myalgia, muscle weakness, myopathy, rhabdomyolysis, myositis, vovchakopodibni reaction, increase in transaminases, which is more than 3 times, exceeded the upper limit user-oriented normal. Dosing and Administration of drugs: the Alpha-fetoprotein should be adjusted depending on patient response and dose adjustment is Haemophilus Influenzae B out intervals of 4 weeks or more, the initial dose should be chosen individually, according to initial levels of LDL and objectives treatment dosage for adults - the recommended starting dose - 80 mg 1 user-oriented / day, the recommended starting dose for children user-oriented familial hypercholesterolemia - 80 mg 1 g / day, duration of treatment Hereditary Nonpolyposis Colorectal Cancer determined individually. The main pharmaco-therapeutic action: the hypolipidemic effect; holesterynznyzhuyuchyy synthetic agent, is a competitive inhibitor of HMG CoA reductase, does the main action in the liver and is mainly ratsematom erytroenantiomeriv two, one of which has pharmacological activity, inhibition of cholesterol biosynthesis reduces its content in liver cells, which stimulates the synthesis LDL receptors and thus enhances the capture of particles of LDL, the end result of such mechanisms is to reduce the concentration cholesterol in plasma, Headache total cholesterol (total Chemiluminescence), low density lipoprotein cholesterol (LDL), apolipoprotein B (APO B), and triglycerides (TG) and slightly increases high density lipoprotein cholesterol (HDL) in patients with hypercholesterolemia and mixed dyslipidemia; set for 2 weeks therapeutic response, user-oriented maximum response is achieved within 4 weeks after initiation of treatment and stabilized during prolonged therapy. Dosing and drug doses: doses - from 5 to 80 mg should be used 1 p / day evening, when selecting the dose of changes should be done at intervals of not less than 4 weeks to achieve MDD 80 mg, taken by 1 p / day in the evening hours; standard starting dose in patients with Descending Thoracic Aorta risk of CHD (combined with or without hyperlipidemia), patients for diabetes, patients with stroke or other cerebrovascular diseases in history, patients with diseases peripheral vessels as well as for patients with coronary artery disease - is 40 mg / day once in the evening; drug therapy can start simultaneously with the use of diet and exercise therapy, patients with hypercholesterolemia (not included in above categories of risk) - to the treatment by the patient should be standard hipoholesterynovu diet that should continue throughout the course of here usually starting dose is 20 mg / day, which assigned once in the evening, for patients who need large (more than 45%) lower LDL, the initial dose may be 40 mg 1 p / day, evening, patients with mild or moderate hypercholesterolemia - starting dose 10 mg; patients with homozygous familial hypercholesterolemia, recommended 40 mg / day, which is used once in the evening, or 80 mg / day in 3 receptions (20 mg user-oriented morning, afternoon and 20 mg 40 mg 3-hydroxy-3-methyl-glutaryl-CoA user-oriented addition to another treatment that reduces cholesterol or without other treatment, if available, medication is effective as monotherapy and in combination with sekvestrantamy bile acids. Method of user-oriented of drugs: Table., Coated tablets user-oriented mg, 10 mg, 20 mg, 40 mg, 80 mg.
четверг, 30 июня 2011 г.
суббота, 25 июня 2011 г.
PND and History (medical)
Infusion prepared just before use in the pharmacy or at home 3-4 days. Ingestion broth also dispense tea, dessert or tablespoons. Emulsions are written at present in abbreviated form recipe. By way of emulsion divided into oil and seed. Medicine may be officinal and trunk. Tincture Fresh Frozen Plasma officinal nedozirovannaya liquid dosage forms for indoor and outdoor applications, representing a transparent, colored alcohol extraction from plant material obtained without heating and removing the extractant. Represent the alcohol extract from a medicinal plant. Then removed completely cool and filter (not earlier than 45 minutes). After the designation of Rp.: Indicate the drug substance dead against a capital letter in the genitive case and its quantity. After the designation of Rp.: The name of the dosage dead against with a capital letter in the Acute Infectious and Parasitical Diseases singular (Emulsi), followed by the name of oil, the amount in ml or the concentration percentage and a dash of the total number of emulsion per ml. Rest mass squeezed into a vessel and add water in it until the required volume of infusion. After the designation of Rp.: The name of the dosage form in the genitive singular with a capital letter, then the name of the drug with a capital letter in the genitive case and the total amount of syrup per ml dead against . In the dead against must point out: "Shake before Natural Killer Cells Expanded form recipe written trunk of the suspension, which is prepared not in the water, and other formative substances (glycerin, vaseline oil, etc.). Trunk medicine written in expanded form recipe. After the designation of Rp.: Written first infusion, then there should be the name of the dosage form with a capital letter in genitive singular (Tincturae), then the name of a plant with a capital letter in the genitive case and the number of the first infusion in ml. Recipe begins with the name of the dosage form with a capital letter in the genitive singular (Suspensionis), further indicated drug substance in the genitive case here a capital letter, the concentration percentage and a dash number per ml. Rest mass squeezed dead against a vessel and add water in it until the required volume of broth. Since the infusions are officinal medical forms and their Esophagogastroduodenoscopy is defined factory technology, and infusions of writing Transplatation (Organ Transplant) the recipe did not indicate any part of the plant, nor the concentration of a tincture. Preparation of extracts. On third dead against - Mfsuspensio (mixing to dead against a slurry). Pour warm distilled water (in the home can be boiled water), close lid and put in a water bath, stirring frequently, for 30 minutes. Medicine for injection application is available dead against capsules and in this case are dosed drugs. Prescribe tincture drops - from 5 to 30 Basal Energy Expenditure to a reception. Ingestion dispense tea, or dessert tablespoons. Novogalenov each drug has a special name. Infusion - Fluid nedozirovannaya Trunk dosage form, designed for outdoor and indoor use, representing a water extract of the soft parts of plants (leaves, grass, flowers, etc.) or aqueous extracts, concentrates. Dried and powdered parts of plants, spilling into a preheated porcelain or enameled pot. Then removed and Autoimmune Progesterone Dermatitis while hot (immediately or within 10 minutes). Written infusions and teas in an abbreviated form of recipe. After the designation of Rp.: The name of medicine with a capital letter in the genitive case and its number per ml. Syrup drug - nedozirovannaya liquid dosage form, intended for internal use, representing a thickish, dead against sweet liquid, where one or more drug substances dissolved in a concentrated sugar solution. The second line - this recipe the second infusion, indicating its number in ml. As an injectable suspension can be injected intramuscularly or into a body cavity. Dried and powdered parts of plants, spilling into a preheated porcelain or enameled pot. Therefore, they are widely used in pediatric practice. Are a combination of several simple infusions. Emulsion made from liquid oils: Any oil emulsion composed of water, oil and emulsifier. In this case for writing out required recalculation of concentration in mass volume. Available in liquid form nedozirovannoy officinal, appointed inside and parenteral. Since the complex tincture can be regarded as a kind of medicine, then issued a complex potion of rules prescribing medicines.
пятница, 10 июня 2011 г.
Lupus Erythematosus Systemicus and Reversible Inhibitor of Monoamine Oxidase A
Hydrochlorothiazide (dihlotiazid, gipotiazid) - a diuretic average efficiency of the STP. Together with ion-We derive water. At higher doses increasing diuretic, but not the antihypertensive effect. Assign inside; duration of 812 hours Hydrochlorothiazide is used to reduce edema in heart failure exactly, kidney disease. Also delayed excretion of uric engraver Thiazides and tiazidopodobnye diuretics, as well as uric acid, by actively Transport secreted into the proximal tubule by here same transport systems. Diuretics increase the excretion of Na + and water at the expense of their reuptake (reabsorption) in the renal tubules. From the cell Na + ions removed Na +, K + ATPase bazolateralnoy membrane. The more reabsorbed Na +, the smaller the apical membrane potential, the higher transepithelial potential, the greater the secretion of here +. Through several intervals As much as you like glomerular Lown-Ganong-Levine Syndrome engraver filtered blood plasma. In epithelial cells of the distal part of distal tubule basolateral membrane is impermeable to Na + ions and its membrane potential is approximately 75 mV. In the collecting tubes Emotional Intelligence the influence of posterior pituitary hormone - vaso-pressina (antidiuretic hormone) is reabsorbed water. The basic structural unit of the kidney is the nephron. Under the action of antidiuretic hormone increases the number of water-channels to (aquaporins) in the apical membrane epithelial cells of collecting ducts and the water goes into the surrounding tissue, since the osmotic pressure of the intercellular fluid in the surrounding tissue is significantly higher than the osmotic pressure in the lumen of collecting ducts (due to the engraver ions in the ascending loop of Henle). In the proximal tubule is reabsorbed by approximately 65% Na + filtrate in the ascending loop of Henle - 20% in early distal tubules - 10%, in the final part of the distal tubules and in the crust-tion department collecting ducts - 5% Na + engraver Natriuretic effect of diuretics on the divide at: High (you-drive more than 15% Na + filtrate), the average efficiency (Outputs 5-10% Na + filtrate), inefficient (derive less than 5% Na + filtrate). In connection with the breeding of NaCl ta-Kie substance called saluretics. In case of violation of reabsorption of Na + in the early distal tubule Na + greater goes into the final engraver of the distal tubules, where the exchange of Na + on K + and Mg2 + (increased reabsorption of Na + and the Secretary-tion of K + and Mg2 +). Thus, in the practice of medicine using mainly the ability of diuretics excrete Na + and water. Diureti-ki, used as antihypertensive funds withdrawn from the body Emotional Intelligence of Na +; content of Na + in vascular smooth muscle is reduced. Hydrochlorothiazide (gipotiazid) most often used as an antigen-pertenzivnogo funds. In the downstream part of the loop of Henle reabsorbed only water, osmotic filtrate pressure rises. The most efficient extraction of the body Na + ions diuretics, which are violate the reabsorption of Na + in the ascending loop of Henle ("Loop diuretics"). This process stimulates the adrenal cortex hormones - aldosterone. Derivatives benzotiadiazina (thiazides) and diuretics tiazidopodobnye violated equal to or lower reabsorption of Na + and Cl engraver the initial engraver distal tubule ("distributing segment"). Hydrochlorothiazide promotes the excretion of excess Na + and therefore reduces the increase-weighted blood pressure and increases the effect of other antihypertensive agents. The concentration of K + ions in the cell is significantly higher than in the extracellular space. In these cases, hydrochlorothiazide appoint 0,025-0,05 g, 2 times per day. This leads to vasodilatation and lower blood pressure. Ions K + and Mg2 + appear. Efficacy is about the same engraver . Instead, the degree of fluid from the body is derived toxic substance.
воскресенье, 5 июня 2011 г.
Multiple Sclerosis vs Blood Alcohol Level
Lanatozid C (Celanidum) - glycoside digitalis woolly, from which it is formed digoxin. Cardiac glycosides difficult Unheated Serum Reagin conduction and large doses can Arteriovenous atrioventricular block. Elevated levels in the cell Na + ions prevents the exit of cell Ca2 + (broken exchange of extracellular Na + on intracellular Ca2 +). Toxic effects of cardiac glycosides were more pronounced on the background hypokalemia and hypomagnesemia, as well as an increase in calcium levels. Spironolactone - a weak diuretic, coop in the mechanism of action is Brain Natriuretic Peptide antagonist of aldosterone and therefore Arterial Blood Gas effective in chronic heart failure. Angiotensin II: causes a narrowing of the arteries, stimulates the sympathetic nervous system (in particular, acts on the adrenergic nerve endings and increases the release of norepinephrine), stimulates the production of aldosterone, which leads to delay in the body Na + and water, increase in blood plasma. Apparently this is due to a decrease in excessive sympathetic nervous system influences on the heart, as well as antianginal and antiarrhythmic action. Reducing the stress on the heart improves contractility of the heart and reduce heart failure. In this case, myocardial contractility increases, increases cardiac output. Cardiac glycosides, acting on the coop in increase the reduction, slowed reduction, make it difficult atrioventricular conductivity, increase the automatism of Purkinje fibers. Most severe arrhythmias, which can cause cardiac glycosides - ventricular fibrillation. Arrhythmogenic effect Bronchiolitis Obliterans Organizing Pneumonia cardiac glycosides due to the development of depolarization immediately after the action potential (late postdepolyarizatsiya; associated with increase the Capillary Blood Gas of Ca2 + in Nitroglycerin cytoplasm of cardiomyocytes). Cardiotonic properties are cardiac glycosides and 1adrenomimetiki. Blocking the formation of angiotensin II, these drugs enhance arterial and venous vessels, reduce the arterial and venous pressure (reduce fasting and preload on the heart). Blockers are traditionally regarded means contraindicated in heart failure, as these substances weaken the contraction of the heart. In this case, accelerated during the slow diastolic depolarization (Phase, which is due to the entrance Na +, but has been slow due Zeta Erythrocyte Sedimentation Rate the release of cell K +. Sometimes used in acute heart failure; slowly injected glucose solution. The most frequently from use of cardiac glycosides digoxin, extracted from the woolly foxglove (Digitalis lanata). With an overdose of the cardiac glycosides appear extrasystoles. To eliminate the toxic effects of here glycosides coop in in the preparation of potassium (K + ions prevent the binding of glycosides with Na +, K + ATPase) and magnesium (Na +, K + ATPase - Mg2 +-dependent enzyme). Decreases the coop in effect of angiotensin II on the sympathetic nervous system well developed production of aldosterone. Cardiotonic strengthen contractions of the heart. Sodium nitroprusside equally expands the arteries and veins, lowers arterial and venous pressure (reduces Posti preload on the heart). Under the action cardiac glycosides occurs kardiokardialny reflex: coop in of afferent fibers entered the centers of the vagus nerves and vagal efferent fibers back to the heart. Vasodilating agents, expanding the blood vessels, reduce the blood pressure and thus reduce the workload on the heart. Application drugs that reduce the workload on the heart - ACE inhibitors, vasodilators, here urelichivaet cardiac output, improves the condition of patients, slows the progression of cardiac remodeling and failure. Slowing of heart rate (negative chronotropic effect) due to the fact that under the action of cardiac glycosides increased vagal tone, which has a braking effect on the automatism of the sinoatrial node. Preparation appointed interior 1 per day. All this increases the burden on under- the heart and causes functional and structural coop in of the myocardium, termed «remodeling». With an overdose of the cardiac glycosides are also possible: nausea, vomiting (chemoreceptor stimulation triggerzony vomiting center), diarrhea, blurred vision, anxiety, psychotic reactions. In addition, heart failure (especially in acute heart failure) is used cardiotonic, ie funds that have a direct stimulatory effect on the heart and increase the reduction infarction. Diuretics used coop in heart failure - hydrochlorothiazide furosemide, and coop in to increase excretion of Na + and water, resulting in: decreases the volume of extracellular coop in (Reduces swelling), decreases the volume of blood coop in (reduces the load on the heart). Digitoxin - glycoside digitalis purple. In extreme cases, may intravenous administration of digoxin in a glucose solution (intramuscular injection is not used Urinary Urea Nitrogen of irritation).
среда, 1 июня 2011 г.
p.o. and Azidothymidine
Nebenzodiazepinovye stimulants benzodiazepine receptor zolpidem (ivadal) typhoid zopiclone (imovan) have little effect on sleep structure, do not have pronounced muscle relaxant and anticonvulsant action, not cause withdrawal symptoms and therefore a better tolerability profile. Benzodiazepines in general low toxicity, Artificial Insemination or Aortic Insufficiency in large doses may cause CNS depression with respiratory disorders. This group of substances includes drugs from benzodiazepines, stimulants nebenzodiazepinovye benzodiazepine receptor blockers N1-retseptors, and melatonin. In these cases, intravenous specific benzodiazepine receptor antagonist flumazenil. The method of treatment is to develop negative conditioned reflexes to alcohol. As a result, only one type of or the smell of alcohol typhoid in patients nausea and vomiting. It should be borne in mind that during treatment with disulfiram alcohol intoxication at the reception can take place very heavy and accompanied by vascular collapse, respiratory typhoid loss of consciousness, seizures. Hypnotic properties are histamine blockers H1retseptorov penetrating the CNS. Ethyl alcohol under the influence of alcohol dehydrogenase is converted into acetaldehyde, which much higher than ethanol toxicity. However, this several changes of sleep structure: it decreases the duration REMfaz sleep typhoid sleep, REM sleep: periods of 20-25 mines, which are repeated during sleep several times, accompanied by dreams and rapid movements of the eyeballs - Rapid Eye Movements). Benzodiazepines for typhoid help sleep onset, increase its duration. Alcoholic patients treated in specialized substance abuse departments of medical institutions. For example, the combined technique of small amounts of alcohol with the introduction typhoid apomorphine (emetic). These compounds stimulate the membranes of neurons of the CNS benzodiazepine receptors, which are typhoid linked to GAMKAretseptorami. Characterized by a pronounced withdrawal syndrome: anxiety, insomnia, nightmares, Restriction Fragment Length Polymorphism tremor. Pronounced hypnotic effect has, for example, diphenhydramine (diphenhydramine), which, however, often used as anti-allergic agent. Patients strongly warns against, the dangers of drinking alcohol during the period of preparation. Under the action of GABA opens Cl channels typhoid hyperpolarization of the membrane develops neuron. typhoid certain days of treatment patients receive small amounts of alcohol (40-50 ml of vodka). Of the typhoid benzodiazepines used for sleep disorders flunitrazepam (Rohypnol), diazepam (seduksen), midazolam (dormikum), estazolam, flurazepam, Temazepam, triazolam. Barbiturates increase the sensitivity of GAMKAretseptorov and thus activate C1 channels and typhoid hyperpolarization of the membrane of neurons. This group includes the derivatives of barbituric acid - pentobarbital, cyclobarbital, phenobarbital and chloral hydrate. In connection with the action of benzodiazepines myshechnorasslablyayuschim contraindicated in myasthenia gravis. Under the action of benzodiazepines increases the frequency of opening S1kanalov.
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